Studies on histamine releasing factor (HRF) of human, murine and guinea-pig origin

There has been the lack of small animal models for the studies of histamine releasing factor (HRF). We have found that HRF produced in vitro by lymphocytes of asthmatic patients can act independently from the animal species and induces histamine secretion from mouse peritoneal mast cells. We also fo...

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Bibliographic Details
Published in:	Agents and Actions Vol. 18; no. 1-2; pp. 163 - 166
Main Authors:	Alam, R, Wyczółkowska, J, Sułowska, Z
Format:	Journal Article
Language:	English
Published:	Switzerland 01-04-1986
Subjects:	Animals Antigens - immunology Biomarkers, Tumor Female Guinea Pigs Histamine Release - drug effects Humans In Vitro Techniques Lymphokines - pharmacology Male Mast Cells - metabolism Mice Mice, Inbred BALB C Mice, Inbred DBA Models, Biological Species Specificity Spleen - metabolism
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Summary:	There has been the lack of small animal models for the studies of histamine releasing factor (HRF). We have found that HRF produced in vitro by lymphocytes of asthmatic patients can act independently from the animal species and induces histamine secretion from mouse peritoneal mast cells. We also found, that spleen cells derived from normal as well as from sensitized mice and guinea-pigs are able to generate HRF in vitro, when cultured in suitable conditions. HRF of mouse and guinea-pig origin released histamine from homologous mast cells in vitro and its activity was enhanced when spleen cell cultures were stimulated with specific antigens or non-specific mitogen.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF01988011