Characterization of sarcoplasmic reticulum ca2+ ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy

Highlights • SERCA impairment has been suggested to occur in DM and in hypothyroid myopathy • SERCA activity and expression of SERCA1 and SERCA2 are not altered in these patients • SERCA1b is expressed at protein level in DM2 and, in lower amount, in DM1 muscle • The reduction of SERCA activity migh...

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Published in:	Neuromuscular disorders : NMD Vol. 26; no. 6; pp. 378 - 385
Main Authors:	Guglielmi, V, Oosterhof, A, Voermans, N.C, Cardani, R, Molenaar, J.P, van Kuppevelt, T.H, Meola, G, van Engelen, B.G, Tomelleri, G, Vattemi, G
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-06-2016
Subjects:	Brody myopathy Hypothyroid myopathy Myotonic dystrophy Neurology Sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 1 (SERCA1) SERCA1b myotonic dystrophy sarcoplasmic/endoplasmic reticulum Ca 2+-ATPase 1 (SERCA1) SERCA1b hypothyroid myopathy Brody myopathy Hypothyroid myopathy Myotonic dystrophy Sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 1 (SERCA1)
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Summary:	Highlights • SERCA impairment has been suggested to occur in DM and in hypothyroid myopathy • SERCA activity and expression of SERCA1 and SERCA2 are not altered in these patients • SERCA1b is expressed at protein level in DM2 and, in lower amount, in DM1 muscle • The reduction of SERCA activity might be specific for Brody myopathy
ISSN:	0960-8966 1873-2364
DOI:	10.1016/j.nmd.2016.04.003