The synthesis and biological evaluation of a series of novel 2-COOC2H5/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents

The synthesis and biological evaluation of a series of novel 2-COOC2H5/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents

O6; A series of novel 1,5-benzothiazepine derivatives containing COOC2H5/COONa groups at the C(2)-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Most of the compounds have been shown...

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Bibliographic Details
Published in:Chinese chemical letters Vol. 20; no. 6; pp. 660 - 662
Main Authors: Zhang, Ping, Wang, Lan Zhi, Wu, Hui Shu, Lan, Jia Ming, Li, Yuan, Wang, Yong Xiang
Format: Journal Article
Language:English
Published: The College of Chemistry & Material Science, Hebei Normal University, Shifiazhuang 050016, China%Department of Pathogenic Biology, Hebei Medical University, Shifiazhuang 050017, China 01-06-2009
Subjects:
1,5-Benzothiazepine
Antibacterial activities
Antifungal
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Summary:O6; A series of novel 1,5-benzothiazepine derivatives containing COOC2H5/COONa groups at the C(2)-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Most of the compounds have been shown to have moderate to good antibacterial activity against S. aureus, S. epidermidis and excellent antifungal activity against C. albicans.
ISSN:1001-8417
DOI:10.1016/j.cclet.2009.01.003