Recognition of guanines at a double helix-coil junction in DNA by a trinuclear copper complex

Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix-coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and...

Full description

Saved in:

Bibliographic Details
Published in:	Chemical communications (Cambridge, England) no. 38; p. 4812
Main Authors:	Ito, Takeo, Thyagarajan, Sunita, Karlin, Kenneth D, Rokita, Steven E
Format:	Journal Article
Language:	English
Published:	England 14-10-2005
Subjects:	Copper - chemistry DNA - chemistry Guanine - chemistry Molecular Structure Organometallic Compounds - chemistry Structure-Activity Relationship
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix-coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.
ISSN:	1359-7345
DOI:	10.1039/b509690a