Nickel-catalyzed asymmetric alpha-arylation of ketone enolates

Nickel-catalyzed asymmetric alpha-arylation of ketone enolates

An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) no. 13; p. 1413
Main Authors: Chen, Guoshu, Kwong, Fuk Yee, Chan, Hoi On, Yu, Wing-Yiu, Chan, Albert S C
Format: Journal Article
Language:English
Published: England 01-01-2006
Subjects:
Catalysis
Ketones - chemistry
Molecular Structure
Nickel - chemistry
Stereoisomerism
Tetralones - chemistry
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Description
Summary:An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.
ISSN:1359-7345
DOI:10.1039/b601691j