The Role of TLR4, TNF‐α and IL‐1β in Type 2 Diabetes Mellitus Development within a North Indian Population

• Published in: Annals of human genetics Vol. 81; no. 4; pp. 141 - 146
• Main Authors: Doody, Natalie E., Dowejko, Monika M., Akam, Elizabeth C., Cox, Nick J., Bhatti, Jasvinder S., Singh, Puneetpal, Mastana, Sarabjit S.
• Format: Journal Article
• Language: English
• Published: England 01-07-2017
• Subjects: Aged; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; IL‐1β‐511; India; Inflammatory gene polymorphisms; Interleukin-1beta - genetics; Logistic Models; Male; Middle Aged; North Indian population; Polymorphism, Genetic; TLR4 896; TNF‐α‐308; Toll-Like Receptor 4 - genetics; Tumor Necrosis Factor-alpha - genetics; Type 2 diabetes mellitus; IL-1β-511; TLR4 896; Type 2 diabetes mellitus; North Indian population; TNF-α-308; Inflammatory gene polymorphisms
• ISSN: 0003-4800; 1469-1809
• DOI: 10.1111/ahg.12197

Summary
This study investigated the role of IL‐1β‐511 (rs16944), TLR4‐896 (rs4986790) and TNF‐α‐308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL‐1β‐511, TLR4‐896 and TNF‐α‐308 loci. The C allele of IL‐1β‐511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32–2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431–22.648]). In this study, we have demonstrated a conclusive association with IL‐1β‐511 locus and IL‐1β‐511‐TLR4‐896 diplotype (CC‐AA) and T2DM, which warrants further comprehensive analyses in larger cohorts.