Integration of the pRB and p53 cell cycle control pathways

Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways are found mutated in all human cancers. These two pathways have typically be...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 51; no. 3; pp. 183 - 204
Main Authors:	Stewart, C L, Soria, A M, Hamel, P A
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-02-2001
Subjects:	Animals Cell Cycle - physiology Cell Death - genetics Cell Division - genetics Chromosome Mapping Humans Retinoblastoma Protein - physiology Tumor Suppressor Protein p53 - physiology
Online Access:	Get full text
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Summary:	Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways are found mutated in all human cancers. These two pathways have typically been studied and described independently. However, as we discuss here, recent data have revealed an intimate molecular and genetic interaction between the p53 and pRB pathways.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0167-594X 1573-7373
DOI:	10.1023/A:1010615822317