Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals

• Published in: Bulletin of experimental biology and medicine Vol. 135; no. 2; pp. 133 - 135
• Main Authors: Litvinova, S V, Kostanyan, I A, Aristova, V V, Kalyuzhnyi, A L, Shul'govskii, V V, Terebilina, N N, Panchenko, L F
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-02-2003
• Subjects: Animals; Animals, Newborn; Brain - metabolism; Drug Tolerance - physiology; Female; Homeostasis; Male; Morphine - pharmacology; Narcotics - metabolism; Neoplasm Proteins - metabolism; Neprilysin - antagonists & inhibitors; Neprilysin - metabolism; Pain - metabolism; Pain Measurement; Peptide Fragments - metabolism; Rats; Rats, Wistar
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/A:1023807512200

We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.