Effect of calcium antagonists on ultrastructure of myocardial microvessels during open heart surgery under conditions of pharmacological and cold cardioplegia

Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution preve...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 132; no. 3; pp. 827 - 831
Main Authors:	Volkov, A M, Kazanskaya, G M, Chasovskikh, G G, D'yakonitsa, T M, Zhdanov, G P, Lomivorotov, V N
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-09-2001
Subjects:	Body Temperature Calcium - antagonists & inhibitors Calcium - metabolism Cardiac Surgical Procedures Child Cold Temperature Heart - drug effects Heart Arrest, Induced Heart Atria - metabolism Heart Atria - ultrastructure Heart Diseases - congenital Humans Hypothermia Ischemia Microcirculation - ultrastructure Microscopy, Electron Myocardium - metabolism Myocardium - ultrastructure Temperature Verapamil - pharmacology
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Summary:	Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic damage to vascular and perivascular structures occurring during reperfusion and body temperature rise.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1013154231069