Pharmacogenetic study of anxiolytic effects of new cholecystokinin receptor antagonists in animals with different levels of emotionality

• Published in: Bulletin of experimental biology and medicine Vol. 135; no. 5; pp. 440 - 444
• Main Authors: Kolik, L G, Gudasheva, T A, Seredenin, S B
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-05-2003
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Behavior, Animal - drug effects; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity - drug effects; Peptides - metabolism; Peptides - pharmacology; Pharmacogenetics; Rats; Receptors, Cholecystokinin - antagonists & inhibitors; Stress, Psychological
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/A:1024907207370

Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers. The test drugs dose-dependently increased the total locomotor activity in the open field test in Balb/c mice and had no effect on the behavior of C57Bl/6 mice. GB-101 (0.4 mg/kg) and GB-115 (0.025 and 0.05 mg/kg) produced an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests. These data confirm anxioselective effects of the test compounds.