Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats

• Published in: Bulletin of experimental biology and medicine Vol. 131; no. 6; p. 544
• Main Authors: Kravchenko, L V, Avren'eva, L I, Guseva, G V, Posdnyakov, A L, Tutel'yan, V A
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-06-2001
• Subjects: Animals; Ascorbic Acid - administration & dosage; Ascorbic Acid - analogs & derivatives; Cytochrome P-450 Enzyme System - metabolism; Diet; Indoles - administration & dosage; Intestinal Mucosa - metabolism; Liver - metabolism; Male; Rats; Rats, Wistar; T-2 Toxin - toxicity; Xenobiotics - metabolism
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/A:1012346401315

Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration.