Rare Extranodal Manifestation of Rosai-Dorfman Disease Presenting as Nasal Obstruction and its Management

• Published in: BMJ case reports Vol. 16; no. 7
• Main Authors: Oui, Ting Jie, Zahedi, Farah Dayana, Husain, Salina, Wan Hamizan, Aneeza Khairiyah
• Format: Journal Article
• Language: English
• Published: England 05-07-2023
• Subjects: Histiocytosis, Sinus - complications; Histiocytosis, Sinus - diagnosis; Histiocytosis, Sinus - pathology; Humans; Nasal Obstruction - etiology; Nose - pathology; Nose Diseases - complications; Nose Diseases - diagnosis; Nose Diseases - pathology; Paranasal Sinuses - pathology; Ear, nose and throat/otolaryngology; Radiology
• ISSN: 1757-790X
• DOI: 10.1136/bcr-2022-251801

Rosai-Dorfman disease (RDD) is a rare and benign lymphoproliferative disorder that commonly presents as painless, bilateral neck swelling. Extranodal presentations are considered rare, but the most common extranodal locations involved include skin, subcutaneous followed by nasal/paranasal sinuses. Although it is a benign condition, it may be mistaken as a malignant lesion and requires a biopsy for diagnostic confirmation. In this study, we report a rare case of RDD with bilateral neck node and nasal/paranasal sinus involvement which initially presented with bilateral nasal obstruction. And, we reviewed the management in this unusual case and discussed the helpful role imaging studies play in the further workup and subsequent follow-up to treatment response.