Implementation of Raman Spectroscopy as an Analytical Tool Throughout the Synthesis of Solid-Phase Scaffolds

• Published in: Applied spectroscopy Vol. 54; no. 11; pp. 1584 - 1590
• Main Authors: Pivonka, Don E., Sparks, Richard B.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-11-2000
• Subjects: Combinatorial chemistry; Raman spectroscopy; On-line analysis
• ISSN: 0003-7028; 1943-3530
• DOI: 10.1366/0003702001948835

Raman spectroscopy has been implemented as an extremely powerful tool for the vibrational analysis of solid-phase synthesis. In this report, the application of both on-line and batch-mode Raman analysis is presented for the comprehensive characterization of a multi-step small-molecule synthesis. Throughout this application, near-infrared Raman spectroscopy also provides unprecedented utility for on-bead qualitative and quantitative investigations. Finally, the on-line experimental procedure presents the first opportunity for open-loop feedback control of solid-phase synthetic parameters through the real-time presentation of reaction progression using Raman spectroscopy.