DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)

• Published in: Química Nova Vol. 45; no. 9; pp. 1092 - 1097
• Main Authors: Roseana A. R. Meireles, Lucas S. Abreu, Joanda Paolla R. e Silva, Andreza B. S. Cavalcanti, Renata Priscila B. de Menezes, Gabriela Cristina S. Rodrigues, Valnês S. Rodrigues Junior, José Iranildo M. de Melo, Massuo Jorge Kato, Vicente Carlos de O. Costa, Marcus Tullius Scotti, Josean F. Tavares
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 01-01-2022
• ISSN: 1678-7064
• DOI: 10.21577/0100-4042.20170932

Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.