Mechanism of antitumor activity of bone marrow natural suppressor cells

Co-culturing of P-815 tumor cell strain and intact mouse bone marrow cells nonadherent to plastic resulted in the appearance of soluble mediators with antitumor activity. Bone marrow cells start releasing these antiproliferative factors only after signal exchange with the target tumor cells. The cel...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 139; no. 2; pp. 238 - 240
Main Authors:	Bel'skii, Yu P, Patrushev, V K, Bel'skaya, N V, Danilets, M G, Trofimova, E S, Agafonov, V I
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-02-2005
Subjects:	Animals Bone Marrow Cells - immunology Cell Communication - immunology Cell Line, Tumor Cell Proliferation Coculture Techniques Mastocytoma - immunology Mice Neoplasms, Experimental - immunology Suppressor Factors, Immunologic - metabolism
Online Access:	Get full text
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Summary:	Co-culturing of P-815 tumor cell strain and intact mouse bone marrow cells nonadherent to plastic resulted in the appearance of soluble mediators with antitumor activity. Bone marrow cells start releasing these antiproliferative factors only after signal exchange with the target tumor cells. The cell-cell contact is an important factor for the induction of antitumor activity. Antitumor activity of bone marrow cells (similarly as immunosuppressive activity) is realized through suppressor factors; the appearance of these factors is induced by target tumor cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0258-6