Gastric and nongastric mechanisms for satiety action of cholecystokinin

• Published in: The American journal of physiology Vol. 254; no. 4 Pt 2; pp. R628 - R632
• Main Authors: Moran, T H, McHugh, P R
• Format: Journal Article
• Language: English
• Published: United States 01-04-1988
• Subjects: Animals; Cholecystokinin - pharmacology; Dose-Response Relationship, Drug; Energy Intake; Gastric Emptying - drug effects; Male; Rats; Rats, Inbred Strains; Reference Values; Satiation - drug effects; Satiety Response - drug effects
• ISSN: 0002-9513
• DOI: 10.1152/ajpregu.1988.254.4.R628

The quantitative relationship between cholecystokinin's (CCK) inhibitory actions on gastric emptying and feeding was examined in rats. CCK (1, 2, 4, or 8 micrograms/kg) inhibited both the gastric emptying (determined by the dye dilution method) and ingestion of a 0.5-kcal/ml glucose solution in a 30-min testing period in 20-h deprived male Sprague-Dawley rats. Comparisons of the inhibitions of gastric emptying and feeding across the dose range of CCK revealed two components of CCK satiety: one defined by a linear relationship between the gastric inhibitory and feeding inhibitory actions of CCK through a dose range of 1-4 micrograms/kg, which accounted for 64% of the variability in the satiety action of CCK, and a second that appeared to be independent of the gastric inhibitory action of CCK.