Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft-versus-host reaction

Induction of chronic graft-versus-host reaction in a semiallogenic DBA/2- (DBA/2xC57Bl/6) F1 system leads to the development of Th1- or Th2-dependent immunopathologies. Modification of the Th1/Th2 ratio during induction with preparations acting on the immune system cells via different mechanisms and...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 140; no. 3; pp. 338 - 340
Main Authors:	Kudaeva, O T, Goiman, E V, Lykov, A P, Kolesnikova, O P, Kozlov, V A
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-09-2005
Subjects:	Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Animals Anti-Glomerular Basement Membrane Disease - etiology Anti-Glomerular Basement Membrane Disease - immunology Benzhydryl Compounds Female Glomerulonephritis - immunology Graft vs Host Reaction - immunology Mice Mice, Inbred C57BL Mice, Inbred DBA Pentoxifylline - pharmacology Phenols - pharmacology Proteinuria - chemically induced Th1 Cells - immunology Th2 Cells - immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Induction of chronic graft-versus-host reaction in a semiallogenic DBA/2- (DBA/2xC57Bl/6) F1 system leads to the development of Th1- or Th2-dependent immunopathologies. Modification of the Th1/Th2 ratio during induction with preparations acting on the immune system cells via different mechanisms and shifting the Th1/Th2 balance towards Th2 (bisphenol A, pentoxifylline, muramyl dipeptide) increases the incidence of Th2-dependent autoimmune lupus-like glomerulonephritis.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0484-y