Colorectal polyps in young adults: a retrospective review of colonoscopy data from Toowoomba and the Darling Downs

• Published in: Internal medicine journal Vol. 54; no. 9; pp. 1471 - 1477
• Main Authors: Liu, Leo, Nagel, Robyn, Verma, Shelley, Pinidiyapathirage, Janani
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01-09-2024; Wiley Subscription Services, Inc
• Subjects: Audits; Cancer; Colonoscopy; Colorectal cancer; Colorectal carcinoma; colorectal polyps; Endoscopy; Gastroenterology; Medical records; neoplastic polyps; Patients; Polyps; regional Australia; Surveillance; Young adults; regional Australia; colorectal polyps; colonoscopy; neoplastic polyps; young adults
• ISSN: 1444-0903; 1445-5994; 1445-5994
• DOI: 10.1111/imj.16420

Background
Polyps are the predominant precursors of colorectal cancer. In the past three decades, the incidence and mortality rates of colorectal cancer have been increasing in adults younger than 50 years.
Aims
The aim of this clinical audit was to evaluate the prevalence, characteristics and clinical associations of polyps in adults aged 18–49 years presenting to an established private gastroenterology clinic in the Toowoomba Darling Downs region.
Methods
The audit included data from 353 patient records held by the Toowoomba Gastroenterology Clinic. Data extracted from patient medical records through the Medical Director program software contained structured endoscopy/colonoscopy and histology reports of excised lesions of patients presenting to the clinic. The extract involved identifying all patients aged 18–49 years in the database from January 2019 to March 2022. Patients were screened based on audit inclusion and exclusion criteria. Patients were risk stratified for recommended surveillance intervals as per Australian Clinical Guidelines.
Results
Of the sample population, 33.4% were identified with polyps and 22.4% were identified with neoplastic polyps (NPs). A total of 6.7% of 18‐ to 29‐year‐old patients were identified with intermediate risk for colorectal cancer (CRC) screening, and 19.8% and 19.3% of 30‐ to 39‐year‐old and 40‐ to 49‐year‐old patients identified with intermediate or high risk for CRC screening respectively. Increased age, greater size of polyps and surveillance of previous polyps were associated with increased NP prevalence.
Conclusions
Data from this audit supported the temporal trend of increasing prevalence of polyps in adults younger than 50 years. Patient cohorts aged 30–39 and 40–49 years may benefit from earlier first colonoscopies. Findings could be the impetus for future research in young adults presenting for colonoscopy.