Inhibition of the nicotinamide adenine dinucleotide-oxidoreductase reaction by herbicides and fungicides of various structures

• Published in: Russian chemical bulletin Vol. 54; no. 5; pp. 1322 - 1327
• Main Authors: Saratovskikh, E. A., Korshunova, L. A., Gvozdev, R. I., Kulikov, A. V.
• Format: Journal Article
• Language: English
• Published: 01-05-2005
• Subjects: Methylococcus capsulatus
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-005-0401-6

The effect of herbicides (basagran, zenkor, kusagard, roundup, setoxidim, and lontrel and lontrel complexes with some doubly charged metal ions) and fungicides (tachigaren and tilt) on the activity of nicotinamide adenine dinucleotide (NADH)-oxidoreductase from the methylotroph Methylococcus capsulatus (strain M) was studied. All the herbicides and fungicides inhibit the enzyme, differing in the degree and type of inhibition. The inhibition constants K sub(i) for these compounds and for lontrel complexes were determined. A correlation between the K sub(i) values and the complexation constants of these pesticides with NADH was established. The studied compounds are toxic.