Synthesis and biological properties of D-homo-6-oxa-8α-analogues of steroid estrogens

Modifications of D-homo-6-oxa-8 alpha -analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other...

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Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 33; no. 3; pp. 288 - 292
Main Authors:	Shavva, A. G., Morozkina, S. N., Ishchenko, I. V., Eliseev, I. I., Selivanov, S. I., Abusalimov, Sh. N., Selivanov, S. S., Kameneva, I. Yu, Eshchenko, N. D.
Format:	Journal Article
Language:	English
Published:	01-05-2007
Online Access:	Get full text
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Summary:	Modifications of D-homo-6-oxa-8 alpha -analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other compounds to the estrogen target organs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1068-1620 1573-9163 1608-330X
DOI:	10.1134/S106816200703003X