Effects of epidermal growth factor on apo B mRNA levels and apo B accumulation in the media of primate hepatocytes in culture

EGF has been shown to augment albumin and apolipoprotein A-I secretion by cynomolgus monkey hepatocytes in primary culture without stimulating cell division. This study was undertaken to determine what effect EGF had on apo B secretion by those hepatocytes. The results indicate that EGF (3 nM final...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 186; no. 1; p. 199
Main Authors:	Blake, W L, Vidmar, T J, Melchior, G W
Format:	Journal Article
Language:	English
Published:	United States 15-07-1992
Subjects:	Analysis of Variance Animals Apolipoprotein A-I - metabolism Apolipoproteins B - genetics Apolipoproteins B - metabolism Cells, Cultured Dose-Response Relationship, Drug Epidermal Growth Factor - pharmacology Kinetics Liver - drug effects Liver - metabolism Macaca fascicularis RNA, Messenger - genetics RNA, Messenger - metabolism Serum Albumin - metabolism Time Factors
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