Is the study of human cancer-associated factors, the best or the only model for human carcinogenesis research? I. The question of helicobacter pylori infection as an accused human gastric carcinogen

• Published in: Biomedicine & pharmacotherapy Vol. 51; no. 1; pp. 1 - 4
• Main Author: Mathé, G
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 1997
• Subjects: Biomarkers, Tumor; gastric carcinogenesis; Gastritis, Atrophic - microbiology; Helicobacter Infections - physiopathology; Helicobacter pylori; human carcinogenesis; Humans; Stomach Neoplasms - microbiology; Helicobacter pylori; human carcinogenesis; gastric carcinogenesis
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/S0753-3322(97)87072-2

Experimental carcinogenesis has discovered and analyzed the inductive effect for one type of cancer, of single factors in given animal strains. Human carcinogenesis analyses the effect of associated factors on one cancer type incidence. It does not find any direct correlation and finds a lot of intermediary effects and mechanism between the factor and established carcinogenesis.
Regarding
Helicobacter pylori (HP), one realizes there is no statistical correlation between gastric infection and carcinoma. The only data which sustain its role is its possible effect in promoting atrophic gastritis with intestinal metaplasia, via the serum pepsinogen 1 reduction due to anti-
HP immunoglobulin A (IgA) antibody. Intestinal metaplasia of the stomach is a condition increasing cell proliferation.