Advances in cellular technology in the hematology field: What have we learned so far?

Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The pre...

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Bibliographic Details
Published in:	World journal of stem cells Vol. 7; no. 1; pp. 106 - 115
Main Authors:	de Souza, Gustavo Torres, Maranduba, Claudinéia Pereira, de Souza, Camila Maurmann, do Amaral, Danielle Luciana Aurora Soares, da Guia, Francisco Carlos, Zanette, Rafaella de Souza Salomão, Rettore, João Vitor Paes, Rabelo, Natana Chaves, Nascimento, Lucas Mendes, Pinto, Ícaro França Navarro, Farani, Júlia Boechat, Neto, Abrahão Elias Hallack, Silva, Fernando de Sá, Maranduba, Carlos Magno da Costa, Atalla, Angelo
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 26-01-2015
Subjects:	Review Reprogramming Progenitor Embryonic stem cells Induced pluripotent stem cells Hematopoietic stem cells
Online Access:	Get full text
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Summary:	Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Author contributions: All the authors contributed to this paper. Telephone: +55-32-40095100 Correspondence to: Angelo Atalla, PhD, Haematology and Bone Marrow Transplantation Service, Medical Clinic Department, University Hospital, Federal University of Juiz de Fora, R José Lourenço Kelmer-Martelos, Juiz de Fora 36036-900, Brazil. angeloatalla@yahoo.com
ISSN:	1948-0210 1948-0210
DOI:	10.4252/wjsc.v7.i1.106