Advances in biomathematical modeling for PET neuroreceptor imaging
The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated advances in biomathematical imaging methodology. We review some of these advances with particular focus on multi-modal image processing, trace...
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| Published in: | Drug discovery today. Technologies Vol. 8; no. 2-4; pp. e45 - e51 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
2011
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| Abstract | The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated advances in biomathematical imaging methodology. We review some of these advances with particular focus on multi-modal image processing, tracer kinetic modeling, occupancy studies and discovery and development of novel radioligands. |
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| AbstractList | The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated advances in biomathematical imaging methodology. We review some of these advances with particular focus on multi-modal image processing, tracer kinetic modeling, occupancy studies and discovery and development of novel radioligands. |
| Author | Salinas, Cristian A. Tziortzi, Andri C. Searle, Graham E. Gunn, Roger N. Guo, Qi |
| Author_xml | – sequence: 1 givenname: Roger N. surname: Gunn fullname: Gunn, Roger N. email: roger.gunn@imanova.co.uk organization: Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK – sequence: 2 givenname: Qi surname: Guo fullname: Guo, Qi organization: Department of Medicine, Imperial College London, London, UK – sequence: 3 givenname: Cristian A. surname: Salinas fullname: Salinas, Cristian A. organization: Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK – sequence: 4 givenname: Andri C. surname: Tziortzi fullname: Tziortzi, Andri C. organization: FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, UK – sequence: 5 givenname: Graham E. surname: Searle fullname: Searle, Graham E. organization: Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK |
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| CitedBy_id | crossref_primary_10_1002_chem_201902243 crossref_primary_10_1016_j_nucmedbio_2014_07_003 crossref_primary_10_1002_hbm_23516 |
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