Adenovirus-5 and adenovirus-37 seropositivity in obese patients

• Published in: Iranian journal of microbiology Vol. 16; no. 5; pp. 684 - 688
• Main Authors: Bostan, Nur Gamze, Altinok, Ozge, Buyukasik, Süleyman, Alis, Halil, Oner, Yasar Ali
• Format: Journal Article
• Language: English
• Published: Tehran University of Medical Sciences 01-10-2024
• Subjects: Adipocytes; Human adenovirus; Infections; Obesity; Original; Serotype
• ISSN: 2008-3289; 2008-4447
• DOI: 10.18502/ijm.v16i5.16804

Background and Objectives: Obesity is a major health issue linked to conditions like diabetes, hypertension, and hy- perlipidemia. Infectobesity suggests that certain microorganisms may contribute to obesity. Human adenovirus serotypes, particularly Human adenovirus type-36 (HAdV-36), Human adenovirus type-5 (HAdV-5), and Human adenovirus type-37 (HAdV-37), are thought to influence body fat regulation. This study investigates the relationship between Immunoglobulin G (IgG) positivity for HAdV-5 and HAdV-37 and obesity, aiming to provide data on the infectious etiology of obesity. Materials and Methods: Blood samples separated into serums from obese (BMI ≥30) and non-obese (BMI 18.5-25) indi- viduals were tested for HAdV-5 and HAdV-37 seropositivity using ELISA kits and seropositivity rates between the groups were compared. Results: HAdV-37 antibody positivity was significantly higher in obese patients (39/48) compared to the control group (24/42) (p=0.011). For HAdV-5, antibody positivity was similar in both groups (26 individuals each) with no significant difference (p=0.461). No significant gender-related differences were found for either serotype. Conclusion: The study suggests HAdV-37 may be associated with obesity, while no such relationship was found for HAdV- There was no gender association for either serotype. These results align with existing literature on HAdV-37, but further research is needed to confirm the link between adenoviruses and obesity and explore potential treatment options.