Exposure to fine particulate matter partially counteract adaptations on glucose metabolism, oxidative stress, and inflammation of endurance exercise in rats

• Published in: Inhalation toxicology Vol. 34; no. 9-10; pp. 287 - 296
• Main Authors: Marmett, Bruna, Dorneles, Gilson Pires, Nunes, Ramiro Barcos, Peres, Alessandra, Romão, Pedro Roosevelt Torres, Rhoden, Cláudia Ramos
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 24-08-2022
• Subjects: Air pollution; cytokines; glucose metabolism; muscle; physical training; redox state
• ISSN: 0895-8378; 1091-7691
• DOI: 10.1080/08958378.2022.2098425

Background: Long-term exposure to air pollution triggers metabolic alterations along with oxidative stress and inflammation, while exercise interventions are widely used to improve those parameters. Objective: Our study aimed to determine the effects of subchronic exposure to particulate matter 2.5 (PM
2.5
) and endurance exercise training on glucose metabolism, oxidative stress, and inflammation of the heart and gastrocnemius muscle of rats. Material and methods: Thirty-two male Wistar rats were assigned to 4 experimental groups: Untrained; Endurance training (ET); Untrained + PM
2.5
; Endurance training + PM
2.5
. Rats exposed to air pollution received 50 µg of PM
2.5
via intranasal instillation daily for 12 weeks. Exercised groups underwent endurance training, consisting in running on an electronic treadmill (70% of maximal capacity, 5 days/week, 5 times/week) for 12 weeks. Glucose metabolism markers, redox state, and inflammatory variables were evaluated in the heart and gastrocnemius muscle. Results: ET and ET + PM
2.5
group had lower body mass gain and higher exercise capacity, and higher glycogen concentration in the heart and gastrocnemius muscle. In the heart, ET and ET + PM
2.5
groups had higher levels of GSH, and lower TBARS and TNF-α concentrations. In the gastrocnemius muscle, the ET group showed higher leptin and lower TBARS and IL-1β concentrations, ET and ET + PM
2.5
showed higher superoxide dismutase activity and ROS content. Conclusion: PM
2.5
exposure partially blunts metabolic and inflammatory adaptations in heart and gastrocnemius muscle tissues induced by exercise training.