Rituximab use in paediatric nephrology practice in Türkiye: TRTX

• Published in: Nephrology (Carlton, Vic.) Vol. 29; no. 5; pp. 259 - 267
• Main Authors: Ünal, Ahmet, Leventoğlu, Emre, Bakkaloğlu, Sevcan A
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01-05-2024
• Subjects: CD20 antigen; Child; Dosage; Genetic engineering; Humans; Monoclonal antibodies; Nephrology; Patients; Pediatrics; Questionnaires; Remission Induction; Retrospective Studies; Rituximab; Rituximab - adverse effects; Treatment Outcome; Turkey; Turkey; anti‐neutrophilic cytoplasmic antibody associated vasculitis; lupus nephritis; antibody‐mediated rejection; nephrotic syndrome; rituximab
• ISSN: 1320-5358; 1440-1797; 1440-1797
• DOI: 10.1111/nep.14265

Rituximab (RTX) is a genetically engineered chimeric monoclonal antibody which binds directly to CD20 antigen and mediates inhibition of B cell development. Although RTX has been widely used in paediatric nephrology, there is no routine protocol for its use. In this study, paediatric nephrologists in Türkiye were asked to fill out a questionnaire to understand their practice in using RTX. This study aimed to determine common practices and clarify the uncertainties regarding the use of RTX in paediatric nephrology.
This was a nationwide, multicenter, retrospective cohort study based on data evaluating the use of RTX in paediatric nephrology practice. An online questionnaire was sent to all paediatric nephrology centers in Türkiye. The questionnaire forms included information about how many patients in total applied RTX treatment, for which indications they use RTX, and whether they made any preparations before using RTX.
According to this survey on RTX use in Türkiye, paediatric nephrologists use it most commonly in SSNS and followed by SRNS, ABMR, SLE and AAV, respectively. Dosing was highly standard but there is significant heterogeneity in pre-exposure tests and patient monitoring in the clinical practice of RTX. Also, the rate of encountering RTX-related allergic and infectious side effects at least once during the professional experience of our physicians can be quite high.
There is an increasing need for the preparation of a guideline on the indications for RTX use for each diagnosis, posology, and the practices to be performed before and after infusion.