Association of a single nucleotide substitution in intergenic region of chromosome 4 with traits of egg quality in domestic chickens

• Published in: Russian journal of genetics Vol. 49; no. 7; pp. 746 - 750
• Main Authors: Barkova, O. Yu, Smaragdov, M. G.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-07-2013
• Subjects: Animal Genetics; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Egg shells; Human Genetics; Microbial Genetics and Genomics; Shell Thickness; Chicken Chromosome; Chicken Line; Shell Weight; Domestic Chicken
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795413070028

The association of SNP2-1 with egg quality traits in domestic chickens was analyzed. SNP2-1 alleles were significantly associated with the thickness of eggshells in chickens of the UK-72 line. The substitution of the SNP2-1 allele
T
for the
C
allele had an effect of 35 ± 15 μm, which corresponds to one standard deviation. For this trait, the effect of the
T
allele was dominant. SNP2-1 was also associated with other traits, including shell weight, egg-laying capacity in 60-week-old chickens (line UK-72), and egg weight in 60-week-old chickens (line cross CD). Thus, the QTL marked with SNP2-1 has a pleiotropic effect that depends on the chicken strain. Candidate genes located on chromosome 4 in close vicinity of SNP2-1 are discussed.