Organophosphate intermediate syndrome with neurological complications of extrapyramidal symptoms in clinical practice

• Published in: Journal of neurosciences in rural practice Vol. 5; no. 3; pp. 298 - 301
• Main Author: Detweiler, Mark
• Format: Journal Article
• Language: English
• Published: United States Medknow Publications 01-07-2014; Medknow Publications and Media Pvt. Ltd
• Subjects: Care and treatment; Health aspects; Organophosphorus compounds; Poisoning; India; intermediate syndrome; adolescent; poisoning; suicide; Organophosphates
• ISSN: 0976-3147; 0976-3155
• DOI: 10.1055/s-0039-1700340

Organophosphates (OPs) are ubiquitous in the world as domestic and industrial agricultural insecticides. Intentional poisoning as suicides attempts are clinical phenomena seen in emergency departments and clinics in agricultural areas. Intermediate syndrome with the neurological complication of extra pyramidal symptoms following acute OP ingestion may occur in pediatric and adult cases. While death is the most serious consequence of toxic OP doses, low levels of exposure and nonfatal doses may disrupt the neurobehavioral development of fetuses and children in addition to bring linked to testicular cancer and male and female infertility. These are disturbing. Chronic and acute toxicity from OPs are barriers to the health of our present and future generations. Symptoms and treatment of acute and chronic OP exposure are briefly referenced with inclusion of the intermediate syndrome. Suggestions for local and systemic reduction of the acute and long term consequences of OP ingestion are opined.