Restriction fragment length polymorphism of the insulin gene in diabetes mellitus

Restriction fragment length polymorphism of the insulin gene in diabetes mellitus

Variant DNA sequences flanking the human insulin gene were found in the Danish population using restriction endonucleases (restriction fragment length polymorphism). The frequencies of these DNA sequences were determined in 47 non-insulin-dependent diabetics and 93 control individuals. We report an...

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Bibliographic Details
Published in:Diabetes (New York, N.Y.) Vol. 31; no. 3; pp. 275 - 277
Main Authors: Owerbach, D, Nerup, J
Format: Journal Article
Language:English
Published: United States 01-03-1982
Subjects:
Base Sequence
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus - genetics
DNA
DNA Restriction Enzymes
Female
Gene Frequency
Genotype
Humans
Insulin - genetics
Male
Pedigree
Polymorphism, Genetic
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Description
Summary:Variant DNA sequences flanking the human insulin gene were found in the Danish population using restriction endonucleases (restriction fragment length polymorphism). The frequencies of these DNA sequences were determined in 47 non-insulin-dependent diabetics and 93 control individuals. We report an association between a restriction fragment length polymorphism of the insulin gene and NIDDM.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0012-1797
1939-327X
DOI:10.2337/diab.31.3.275