Relapsing polychondritis or relapsing polychondritis-like symptoms associated with IgG4-RD. Case reports and review of the literature

• Published in: Modern rheumatology case reports Vol. 6; no. 1; pp. 106 - 110
• Main Authors: Gallo, Jesica Romina, Schmid, Maria Marcela, Yanzi, Josefina Gallino, Paira, Sergio Oscar
• Format: Journal Article
• Language: English
• Published: England 07-01-2022
• Subjects: Autoimmune Diseases - diagnosis; Humans; Immunoglobulin G; Immunoglobulin G4-Related Disease - diagnosis; Polychondritis, Relapsing - diagnosis; relapsing polychondritis (RP); RP-like symptoms; IgG4-RD
• ISSN: 2472-5625; 2472-5625
• DOI: 10.1093/mrcr/rxab033

Relapsing polychondritis (RP) is a rare systemic disorder characterised by recurrent, widespread chondritis of the auricular, nasal, and tracheal cartilages. Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised by the infiltration of IgG4-bearing plasma cells into systemic organs. However, 25-35% of patients with RP have a concurrent autoimmune disease. The coexistence of RP and IgG4 is rare considering that, to the best of our knowledge, there are only four previous reports of RP or RP-like symptoms associated with IgG4-RD. We herein report two cases which could be RP or RP-like symptoms associated with IgG4-RD.