Hypersensitivity to efavirenz treated with corticosteroids in a 6-year-old child

We report a case of the successful use of corticosteroids to treat hypersensitivity caused by efavirenz in a pediatric patient. A 6-year-old HIV-infected patient developed a diffuse erythematous rash and fever after being switched to a regimen containing efavirenz. Use of prednisone at a dose of 1 m...

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Bibliographic Details
Published in:	AIDS patient care and STDs Vol. 17; no. 1; p. 1
Main Authors:	Foti, Jeffrey L, Piatt, Janice P
Format:	Journal Article
Language:	English
Published:	United States 01-01-2003
Subjects:	Anti-HIV Agents - adverse effects Benzoxazines Child Drug Administration Schedule Female HIV Infections - drug therapy Humans Hypersensitivity - drug therapy Hypersensitivity - etiology Oxazines - adverse effects Prednisone - administration & dosage Prednisone - therapeutic use Reverse Transcriptase Inhibitors - adverse effects
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Summary:	We report a case of the successful use of corticosteroids to treat hypersensitivity caused by efavirenz in a pediatric patient. A 6-year-old HIV-infected patient developed a diffuse erythematous rash and fever after being switched to a regimen containing efavirenz. Use of prednisone at a dose of 1 mg/kg every other day for 2 weeks on rechallenge resulted in successful reinstitution of the regimen.
ISSN:	1087-2914
DOI:	10.1089/108729103321042854