Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

• Published in: Nano biomedicine and engineering Vol. 12; no. 3; pp. 253 - 261
• Main Authors: Ismail, Ahmad Hussein, Al-Bairmani, Hassanain Kamil, Abbas, Zainab Sabri, Rheima, Ahmed Mahdi
• Format: Journal Article
• Language: English
• Published: Tsinghua University Press 18-09-2020
• Subjects: bacterial strains; nanoscale complexes; tem; theophylline; ultrasonic method
• ISSN: 2150-5578; 2150-5578
• DOI: 10.5101/nbe.v12i3.p253-261

Three nanocomplexes of Zn(Ⅱ), Mn(Ⅱ), Fe(Ⅱ) with theophylline were synthesized by ultrasonic sonication method. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-vis) spectroscopy and C/H/N elemental analyses were used to investigate and suggest the structure of the nanocomplexes. Size and morphology of the nanocomplexes were measurement by transmission electron microscopy (TEM), ranging from 6-22 nm. Efficacy of the nanocomplexes synthesized was examined against four types of bacterial strains: Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Klebsiella pneumonia and Escherichia coli (Gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as indicated by their inhibition zones between 98% and 100%.