THYROID DYSFUNCTION CAUSED BY MATERNAL AUTOIMMUNE THYROIDITIS: TWO DIFFERENT CLINICAL PICTURES IN TWO SIBLINGS

• Published in: Acta endocrinologica (Bucharest, Romania : 2005) Vol. 19; no. 3; pp. 386 - 389
• Main Authors: Yilmaz, G Can, Anik, A
• Format: Journal Article
• Language: English
• Published: Romania The Publishing House of the Romanian Academy 01-07-2023
• Subjects: Case Report; transient neonatal hypothyroidism; Neonatal thyrotoxicosis; maternal autoimmune thyroiditis
• ISSN: 1841-0987; 1843-066X
• DOI: 10.4183/aeb.2023.386

Maternal antibodies in cases of chronic autoimmune thyroiditis may be transferred to the baby via the transplacental route, leading to transient hyperthyroidism or hypothyroidism. The development of hyperthyroidism in one sibling and hypothyroidism in the other, however, is an extremely rare condition. We present two siblings, one with transient neonatal hyperthyroidism and the other with transient neonatal hypothyroidism, born to a euthyroid mother who was being treated for Hashimoto's thyroiditis.
A term male baby was evaluated due to tachycardia, high fT4 and low TSH. Following a diagnosis of Neonatal thyrotoxicosis, the patient was started on methimazole and propranolol treatments. The doses were gradually reduced and methimazole was stopped in the 5
month of treatment.
A male baby was referred with elevated TSH identified in the neonatal screening program, with TSH >100 mIU/L and fT4 7.5 pmol/l (N: 12-22) found in a venous blood sample. The patient was started on 50 µg/day LT4, which was gradually decreased and stopped when the baby was 5.5 months old.
It should be kept in mind that antibodies may change character in mothers with autoimmune thyroiditis, and may cause different clinical pictures in babies in different pregnancies.