Influence of integrin-binding motif (RGD) on the attachment and internalization of avian adenovirus CELO in mammalian cells

Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments in vitro revealed that the introduction of an RGD motif into the fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised th...

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Bibliographic Details
Published in:	Molecular genetics, microbiology and virology Vol. 23; no. 2; pp. 89 - 93
Main Authors:	Zubkova, O. V., Logunov, D. Y., Karpov, A. P., Shmarov, M. M., Belousova, R. V., Naroditsky, B. S.
Format:	Journal Article
Language:	English
Published:	Heidelberg Allerton Press, Inc 01-06-2008
Subjects:	Adenovirus Biomedical and Life Sciences Experimental Articles Life Sciences Microbiology Molecular Medicine Virus Binding PacI Cell Integrins Virus Internalization Viral Particle
Online Access:	Get full text
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Summary:	Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments in vitro revealed that the introduction of an RGD motif into the fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised the efficiency of the process of internalization of the virus both in CAR-positive and in CAR-negative cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-4168 1934-841X
DOI:	10.3103/S0891416808020067