Effect of algal metabolites in the inhibition of angiogenic channels for breast tumour

• Published in: Aquaculture international Vol. 31; no. 5; pp. 2825 - 2848
• Main Authors: Banerjee, Risav, Das, Rajdeep, VM, Amrutha, S, Asha Devi, R, Sudhakaran
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-10-2023; Springer Nature B.V
• Subjects: Algae; Bioactive compounds; Biologically grown products; Biomedical and Life Sciences; Blood vessels; Breast cancer; Cancer; Channels; Freshwater & Marine Ecology; Life Sciences; Marine ecology; Metabolites; Women; Zoology; Breast carcinoma; Secondary metabolites; VEGF inhibition; Angiogenic inhibition
• ISSN: 0967-6120; 1573-143X
• DOI: 10.1007/s10499-023-01110-x

Breast cancer is a leading cause of cancer-related deaths among women worldwide. Angiogenesis, the process of the formation of new blood vessels, plays a crucial role in the development and progression of breast cancer. In recent years, marine algal bio-products have garnered attention as a potential alternative to traditional chemotherapeutics for the treatment of breast cancer. Marine algae, which are itself a vast universe to explore in the marine ecology, are rich sources of bioactive compounds with diverse pharmacological activities, including that of the anti-angiogenic properties. In this review, we aim to summarize the current state of knowledge on the use of marine algal bio-products for targeting angiogenic channels in the treatment of breast cancer. In this paper, we reviewed potential use case scenarios for algal metabolites’ anti-angiogenic inhibition of human breast cancers, discussed the various types of marine algal bio-products that have been studied for their anti-angiogenic effects, and discussed the mechanisms of action by which they exert these effects. We also examined the potential benefits and drawbacks of marine algal bio-products as anti-angiogenic agents, as well as the future avenues for study in this area.