Effect of bee venom on rat glucocorticoid receptor beta : a therapeutically model of rheumatoid arthritis

• Published in: Iraqi journal of veterinary sciences Vol. 32; no. 2; pp. 127 - 133
• Main Authors: al-Hasnawi, Ala Tariq Shakir, al-Rabii, Hadi Mazal, Mahdi, Rasha Kazim
• Format: Journal Article
• Language: Arabic; English
• Published: Mosul, Iraq University of Mosul, College of Veterinary Medicine 28-01-2019
• Subjects: bee venom; glucocorticoid receptor beta; rheumatoid arthritis
• ISSN: 1607-3894; 2071-1255; 2071-1255
• DOI: 10.33899/ijvs.2019.153838

This study aim to use bee venom as alternative medicine for treatment of rats induced with rheumatoid arthritis. Forty rats
used for this purpose which divided into four groups, three groups induced with rheumatoid arthritis and one group considered
as control group that subdivided into control negative and control positive (rheumatoid group). All the groups induced with
rheumatoid arthritis injected with bee venom with different doses (high 40 μg/kg and low dose 10 μg/kg) and different times
(after 5 days and after two weeks from CFA injection and along with CFA injection). Glucocorticoid receptor beta used as a
biomarker which suggested function as negative regulator determine glucocorticoid sensitivity in target tissues and as an
endogenous inhibitor for glucocorticoid action. The high and low dose showed significantly decrease in GCRβ as compared
with control group and non-significant between rheumatoid and both along CFA and after 5 days of CFA injection. The pretreatment
high and low dose revealed significant decrease in GCRβ compared with Rheumatoid group and non- significant as
compared with control group in low dose bee venom treatment. Also, depending on hand paw edema assessment, a weak
evidence about anti-inflammatory effects of bee venom has shown. From our data we concluded that bee venom prevents
GCRβ elevation especially in pre-treatment group this may result assess to anti-inflammatory effect but the safety of this toxin
still needed for another study. Clinically no evidence about the treated effect of bee venom on rheumatoid arthritis in rat.