Effect of hypoxia and indomethacin on activities of digestive enzymes in rats at various stages of postnatal ontogenesis

• Published in: Journal of evolutionary biochemistry and physiology Vol. 48; no. 3; pp. 343 - 345
• Main Authors: Nikitina, A. A., Bagaeva, T. P., Dmitrieva, Yu. V., Egorova, V. V.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-05-2012; Springer Nature B.V
• Subjects: Animal Physiology; Biochemistry; Biomedical and Life Sciences; Digestive system; Enzymes; Epigenetics; Evolutionary Biology; Hypoxia; Life Sciences; Rodents; Short Communications; Evolutionary Biochemistry; Indomethacin; Digestive Enzyme; Hypobaric Hypoxia; Corticosterone
• ISSN: 0022-0930; 1608-3202
• DOI: 10.1134/S0022093012030115

A study found that hypoxia experienced at the neonatal period preserves its trace in 3-month old rats, which is manifested as an increase of activities of digestive enzymes. It has been shown for the first time that at the repeated stress of these animals with indomethacin, activities of digestive enzymes change to the lesser degree than at the single stress at the early postnatal period, which seems to indicate a decrease of the level of the stress response. In works on other objects the epigenetic mechanism of the post-stress regulation is shown sufficiently convincingly. Possibly, functioning of enzymes of small intestine in a different regime also can be explained by the changes occurring at the epigenetic level. We have failed to reveal in the literature the direct proofs about the mechanism of these changes performed specifically for the small intestine enzymes.