The Effect of Iodine and Selenium Preparations on the Course and Outcome of Acute Radiation Damage

• Published in: Biology bulletin of the Russian Academy of Sciences Vol. 49; no. 11; pp. 2055 - 2064
• Main Authors: Vasiliev, R. O., Drachev, I. S., Yugatova, N. Yu, Troshin, E. I., Myasnikov, V. A., Grebenyuk, A. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-12-2022; Springer Nature B.V
• Subjects: Antimicrobial activity; Biochemistry; Biomedical and Life Sciences; Cell Biology; Ecology; Feed additives; Iodine; Leukocytes; Leukopenia; Life Sciences; Modification of Radiation Effects; Peripheral blood; Radiation; Selenium; Selenium compounds; Thrombocytopenia; Zoology; γ Radiation; iodophore; radioprotective effect; acute radiation syndrome; DAFS-25k; Monclavit-1; gastrointestinal syndrome; irradiation
• ISSN: 1062-3590; 1608-3059
• DOI: 10.1134/S1062359022110218

In experiments on mice, the radioprotective and therapeutic effectiveness of the combined use of the selenium-containing feed additive DAFS-25k and the iodine-containing drug Monclavit-1 was studied. It was shown that intragastric administration of an oil solution of DAFS-25k three hours before the total external single exposure to
137
Cs γ-radiation, at a dose of 6.0 Gy, at a dose rate of 0.99 Gy/min followed by intragastric administration of an aqueous solution of Monclavit-1 after 12 hours increases the survival rate of irradiated animals to 67% against 17% in the control. At the same time, the frequency of gastrointestinal syndrome in the mice with the combined use of DAFS-25k in the dose range before irradiation and Monclavit-1 after irradiation decreased to 50 and 42% against 100% in the control of irradiation. Supplements of iodine and selenium in the composition of the DAFS-25k and Monclavit-1 drugs favorably affect the absolute content of leukocytes and platelets in the peripheral blood of the irradiated mice, reducing the severity of leukocytopenia and thrombocytopenia during the “height” of acute radiation damage and accelerating the recovery of the population of these shaped elements. It is assumed that the possible mechanisms of radioprotective effectiveness are the antioxidant activity of selenium compounds in DAFS-25k and normalization of thyroid function and relief of gastrointestinal syndrome through the expressed antimicrobial activity of Monclavit-1.