The influence of adverse drug effects on health-related quality of life in chronic obstructive pulmonary disease patients

• Published in: The International journal of pharmacy practice Vol. 30; no. 5; pp. 457 - 465
• Main Authors: Altawalbeh, Shoroq M, Almomani, Basima A, Alefan, Qais, Mohammad Momany, Suleiman, Al-Share, Qusai Y
• Format: Journal Article
• Language: English
• Published: 04-11-2022
• ISSN: 0961-7671; 2042-7174
• DOI: 10.1093/ijpp/riac052

Abstract Objectives Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Concerns have been raised about the influence of adverse drug effects on patient’s health-related quality of life (HRQoL) in COPD patients. This study aimed to evaluate the impact of COPD treatment-related adverse effects on HRQoL in COPD patients. Methods In a cross-sectional study, COPD patients aged 40 years or older were identified and interviewed during their hospital visits. The EuroQol 5 Dimension 5 Level (EQ-5D-5L) questionnaire was used for evaluating HRQoL. Potential treatment adverse effects were evaluated as experienced by participants during the last 2 weeks preceding the interview. The intensity of adverse effects was reported in the following categories: never, mild, moderate and severe. Multivariable linear regression model was performed to evaluate the influence of adverse drug effects on utility scores as an indicator of HRQoL. Key findings A total of 203 patients diagnosed with COPD were recruited in the current study. The mean utility score of the study sample was 0.68 (SD = 0.36). Moderate-severe constipation, moderate-severe confusion, mild urinary hesitation, moderate-severe urinary hesitation, moderate-severe dry eyes and moderate-severe drowsiness were significant predictors/determinants for the average utility scores (coefficients were −0.099, −0.191, −0.111, −0.157 and −0.144, respectively). In addition, having higher COPD Assessment Test scores and severe disease was negatively associated with average utility scores (coefficients were −0.287 and −0.124, respectively). Conclusions Higher intensity of COPD treatment-related adverse effects has a negative influence on HRQoL in COPD patients. Anticholinergic drug effects are of concern in COPD adults’ population.