1,5-Diketone derivatives in the synthesis of 2,6-diaryl-4-(pyridin-4-yl)pyridines

1,5-Diketone derivatives in the synthesis of 2,6-diaryl-4-(pyridin-4-yl)pyridines

New 1,5-diaryl-3-(pyridin-4′-yl)pentane-1,5-diones were synthesized via the tandem reaction of pyridin-4-carbaldehyde with methyl (aryl) ketones in the presence of sodium hydride. The treatment of the diketones with ammonium acetate resulted in heterocyclization to 2,6-diaryl-4-(pyridin-4′-yl)pyridi...

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Bibliographic Details
Published in:Russian chemical bulletin Vol. 70; no. 1; pp. 191 - 194
Main Authors: Vasilyeva, T. P., Vorobyeva, D. V.
Format: Journal Article
Language:English
Published: New York Springer US 2021
Springer Nature B.V
Subjects:
Ammonium acetate
Aromatic compounds
Brief Communications
Cascade chemical reactions
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diketones
Inorganic Chemistry
Ketones
Organic Chemistry
Pyridines
Sodium hydrides
bipyridines
cross-coupling reaction
methyl (aryl) ketones
heterocyclization
pyridin-4-carbaldehyde
Michael reaction
1,5-diketones
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Summary:New 1,5-diaryl-3-(pyridin-4′-yl)pentane-1,5-diones were synthesized via the tandem reaction of pyridin-4-carbaldehyde with methyl (aryl) ketones in the presence of sodium hydride. The treatment of the diketones with ammonium acetate resulted in heterocyclization to 2,6-diaryl-4-(pyridin-4′-yl)pyridines.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3076-8