Hierarchical Self‐Assembled Photo‐Responsive Tubisomes from a Cyclic Peptide‐Bridged Amphiphilic Block Copolymer

• Published in: Angewandte Chemie Vol. 132; no. 23; pp. 8945 - 8948
• Main Authors: Yang, Jie, Song, Ji‐Inn, Song, Qiao, Rho, Julia Y., Mansfield, Edward D. H., Hall, Stephen C. L., Sambrook, Megan, Huang, Feihe, Perrier, Sébastien
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 02-06-2020
• Subjects: Block copolymers; Chemistry; Copolymers; Drug carriers; Drug delivery; Micelles; Morphology; Nanoröhren; Nanostructure; Peptid-Polymer-Konjugate; Peptides; Photoresponsive Materialien; Tubisomen; Wirkstoffbeladung
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.201916111

Typically, the morphologies of the self‐assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarchical self‐assembly of cyclic peptide‐bridged amphiphilic diblock copolymers. The capacity of obtained photo‐responsive tubisomes as potential drug carriers is evaluated. The supramolecular tubisomes pave an alternative way for fabricating polymeric tubular structures, and will expand the toolbox for the rational design of functional hierarchical nanostructures.
Hierarchische supramolekulare Selbstassemblierung eines über ein cyclisches Peptid verbrückten, funktionellen amphiphilen Diblock‐Copolymers führt zu photoresponsiven Tubisomen in Wasser. Die Tubisomen werden als photokontrollierte Wirkstofftransportvehikel für den Krebswirkstoff Doxorubicin eingesetzt und erreichen eine erhöhte intrazelluläre DOX‐Freisetzung und verbesserte Antitumoraktivität.