Acquired haemolytic anaemia due to isohaemagglutinins of donor origin following ABO-minor-incompatible kidney transplantation

Of 1041 renal allograft transplantations performed in our centre, 142 (13.6%) were carried out with ABO-minor-incompatible kidneys. Anti-recipient ABO antibodies were found in two of 34 patients treated with cyclosporin. These two cases of severe but self-limited haemolysis due to anti-A1 and anti-B...

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Bibliographic Details
Published in:	Nephrology, dialysis, transplantation Vol. 5; no. 2; p. 148
Main Authors:	Povlsen, J V, Rasmussen, A, Hansen, H E, Fjeldborg, O, Kissmeyer-Nielsen, F, Madsen, M
Format:	Journal Article
Language:	English
Published:	England 1990
Subjects:	ABO Blood-Group System - immunology Adult Anemia, Hemolytic - etiology Azathioprine - therapeutic use Cyclosporins - therapeutic use Female Hemagglutinins - immunology Humans Kidney Transplantation Male
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Summary:	Of 1041 renal allograft transplantations performed in our centre, 142 (13.6%) were carried out with ABO-minor-incompatible kidneys. Anti-recipient ABO antibodies were found in two of 34 patients treated with cyclosporin. These two cases of severe but self-limited haemolysis due to anti-A1 and anti-B, respectively, are reported in detail. Among 108 azathioprine-treated patients no evidence of the disorder was found. The condition should be suspected in any recipient with an unexpected reduction in haematrocrit or other signs of haemolysis after ABO-minor-incompatible organ transplantation.
ISSN:	0931-0509
DOI:	10.1093/ndt/5.2.148