A Rare Case of Laryngeal Osteosarcoma Causing Diagnostic Challenges

Laryngeal osteosarcomas are extremely rare. They cause diagnostic difficulty for the otolaryngologist and pathologist. Differentiation from sarcomatoid carcinoma is challenging but important, as clinical features and treatment strategies are different. Total laryngectomy is generally the preferred s...

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Published in:	Curēus (Palo Alto, CA) Vol. 15; no. 4; p. e37393
Main Authors:	Kumbul, Yusuf Ç, Akın, Vural, Yasan, Hasan, Özdoğan Yılmaz, Gizem, Ayyıldız, Veysel A
Format:	Journal Article
Language:	English
Published:	United States Cureus Inc 10-04-2023 Cureus
Subjects:	Alcohol Biopsy Bone cancer Cartilage Case reports Chemotherapy Chronic obstructive pulmonary disease Cytokeratin Dyspnea Endoscopy Fibrosarcoma General anesthesia Hyperthyroidism Larynx Lymphatic system Medical diagnosis Metastasis Otolaryngology Pagets disease Pathology Radiation therapy Radiology Risk factors Sarcoma Smoking Thyroid gland histopathological examination laryngeal osteosarcomas sarcomatoid carcinomas diagnostic challenges total laryngectomy
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Abstract	Laryngeal osteosarcomas are extremely rare. They cause diagnostic difficulty for the otolaryngologist and pathologist. Differentiation from sarcomatoid carcinoma is challenging but important, as clinical features and treatment strategies are different. Total laryngectomy is generally the preferred surgical approach for laryngeal osteosarcomas. Since lymph node metastasis is not expected, neck dissection is not needed. In this report, we present a case diagnosed with laryngeal osteosarcoma post the examination of the total laryngectomy specimen of a laryngeal tumor that could not be histopathologically differentiated by punch biopsy.
AbstractList	Laryngeal osteosarcomas are extremely rare. They cause diagnostic difficulty for the otolaryngologist and pathologist. Differentiation from sarcomatoid carcinoma is challenging but important, as clinical features and treatment strategies are different. Total laryngectomy is generally the preferred surgical approach for laryngeal osteosarcomas. Since lymph node metastasis is not expected, neck dissection is not needed. In this report, we present a case diagnosed with laryngeal osteosarcoma post the examination of the total laryngectomy specimen of a laryngeal tumor that could not be histopathologically differentiated by punch biopsy. Laryngeal osteosarcomas are extremely rare. They cause diagnostic difficulty for the otolaryngologist and pathologist. Differentiation from sarcomatoid carcinoma is challenging but important, as clinical features and treatment strategies are different. Total laryngectomy is generally the preferred surgical approach for laryngeal osteosarcomas. Since lymph node metastasis is not expected, neck dissection is not needed. In this report, we present a case diagnosed with laryngeal osteosarcoma post the examination of the total laryngectomy specimen of a laryngeal tumor that could not be histopathologically differentiated by punch biopsy.
Author	Kumbul, Yusuf Ç Yasan, Hasan Özdoğan Yılmaz, Gizem Akın, Vural Ayyıldız, Veysel A
AuthorAffiliation	2 Medical Pathology, Suleyman Demirel University, Isparta, TUR 1 Otorhinolaryngology and Head and Neck Surgery, Suleyman Demirel University, Isparta, TUR 3 Radiology, Suleyman Demirel University, Isparta, TUR
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/37182021$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1097/01.mlg.0000150672.45484.5c 10.1002/hed.23767 10.1016/j.amjoto.2010.09.002 10.1007/s12105-014-0550-8 10.4081/rt.2017.6955 10.1002/cncr.11716 10.1007/s40487-020-00110-8
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Copyright	Copyright © 2023, Kumbul et al. Copyright © 2023, Kumbul et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2023, Kumbul et al. 2023 Kumbul et al.
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Keywords	histopathological examination laryngeal osteosarcomas sarcomatoid carcinomas diagnostic challenges total laryngectomy
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References	Smith RB (ref7) 2003; 98 Mäkitie AA (ref1) 2020; 8 Mosalleum E (ref2) 2015; 9 Mendenhall WM (ref6) 2011; 32 Sanaat Z (ref3) 2009; 12 Athré RS (ref4) 2005; 115 Arslan M (ref5) 2008; 13 Bennion NR (ref9) 2017; 9 Kuba K (ref8) 2015; 37
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Snippet	Laryngeal osteosarcomas are extremely rare. They cause diagnostic difficulty for the otolaryngologist and pathologist. Differentiation from sarcomatoid...
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SubjectTerms	Alcohol Biopsy Bone cancer Cartilage Case reports Chemotherapy Chronic obstructive pulmonary disease Cytokeratin Dyspnea Endoscopy Fibrosarcoma General anesthesia Hyperthyroidism Larynx Lymphatic system Medical diagnosis Metastasis Otolaryngology Pagets disease Pathology Radiation therapy Radiology Risk factors Sarcoma Smoking Thyroid gland
Title	A Rare Case of Laryngeal Osteosarcoma Causing Diagnostic Challenges
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