Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8 + T-cells promotes their mechanotransduction and activation

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8 T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can b...

Full description

Bibliographic Details

Published in:	Chemical communications (Cambridge, England) Vol. 57; no. 94; p. 12667
Main Authors:	Li, Rui, Ali, Walida, Ma, Chao, Bajpai, Apratim, Luu, Ngoc, Varshney, Aarushi, Rowe, Camden Riley, Chen, Weiqiang
Format:	Journal Article
Language:	English
Published:	England 25-11-2021
Subjects:	CD8-Positive T-Lymphocytes - metabolism Humans Ligands Mechanotransduction, Cellular Oligopeptides - metabolism Surface Properties Wnt Signaling Pathway Wnt-5a Protein - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!