Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8 + T-cells promotes their mechanotransduction and activation

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8 + T-cells promotes their mechanotransduction and activation

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8 T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can b...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 57; no. 94; p. 12667
Main Authors: Li, Rui, Ali, Walida, Ma, Chao, Bajpai, Apratim, Luu, Ngoc, Varshney, Aarushi, Rowe, Camden Riley, Chen, Weiqiang
Format: Journal Article
Language:English
Published: England 25-11-2021
Subjects:
CD8-Positive T-Lymphocytes - metabolism
Humans
Ligands
Mechanotransduction, Cellular
Oligopeptides - metabolism
Surface Properties
Wnt Signaling Pathway
Wnt-5a Protein - metabolism
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Summary:We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8 T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.
ISSN:1364-548X
DOI:10.1039/d1cc05194f