Age-related changes in albumin and actin of human myocardium

• Published in: Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 2; no. 2; pp. 160 - 165
• Main Authors: Kovalyova, M. A., Kovalyov, L. I., Serebryakova, M. V., Moshkovskii, S. A., Shishkin, S. S.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-06-2008; Springer Nature B.V
• Subjects: Age; Bioorganic Chemistry; Cardiovascular disease; Chemistry; Chemistry and Materials Science; Experimental Studies; Genomics; Medicinal Chemistry; Molecular biology; Proteins; Proteomics; myocardium; man; proteomics; age-related changes
• ISSN: 1990-7508; 1990-7516
• DOI: 10.1134/S1990750808020054

Proteomic technologies revealed products of 2 genes (α-actin and albumin) in a human myocardium tissue. They exist as fragments and their appearance and increased content correlated with age. The age-related variants differ from the mature forms of these proteins by the absence of N-terminal fragments of the amino acid sequences. In the chronic ischemic heart disease (CIHD), these age-related proteins were found in 50% of cases (in the age group 31–40 years), whereas in the control group such combination was detected only in 10% of the examined individuals. Subsequent studies in this field would probably reveal molecular mechanisms responsible for impairment and/or ageing of the myocardium and also of adaptation/disadaptation mechanisms in the CIHD.