Hydralazine-Induced Antineutrophilic Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting as Crescentic Glomerulonephritis

Hydralazine is a vasodilator medication commonly used for treating hypertension. While generally well-tolerated, in rare cases it can induce autoimmune reactions, including anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This case report presents a patient who developed ANCA-assoc...

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Bibliographic Details
Published in:	Curēus (Palo Alto, CA) Vol. 16; no. 4; p. e59100
Main Authors:	Rodriguez, Yoan E, Zahoor, Hovra, Patel, Kunal, Castro Ruiz, Christian, Shahoori, Neda
Format:	Journal Article
Language:	English
Published:	United States Cureus Inc 26-04-2024 Cureus
Subjects:	Antibodies Biopsy Blood tests Creatinine Diabetes Hemoglobin Hypertension Internal Medicine Kidney diseases Lupus Nephrology Rheumatology Serology Urinalysis Urine Florida United States > US small vessel vasculitis pauci-immune vasculitis anca-associated vasculitis (aav) hydralazine necrotizing and crescentic glomerulonephritis
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Summary:	Hydralazine is a vasodilator medication commonly used for treating hypertension. While generally well-tolerated, in rare cases it can induce autoimmune reactions, including anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This case report presents a patient who developed ANCA-associated vasculitis resulting in crescentic glomerulonephritis (CrGN) following long-term hydralazine therapy, highlighting the importance of considering this rare adverse effect in patients with unexplained renal decline.
ISSN:	2168-8184 2168-8184
DOI:	10.7759/cureus.59100