Induction of micronuclei in mouse bone marrow after combined X-rays-cyclophosphamide and X-rays-mitomycin C treatments
The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X‐rays and cyclophosphamide (CP) or X‐rays and mitomycin C (MMC) were investigated. Combinations of high (1.00 Gy + 100 mg/kg bw CP and 1.00 Gy + 5.25 mg/kg bw MMC) and low (0.25...
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| Published in: | Teratogenesis, carcinogenesis, and mutagenesis Vol. 19; no. 4; pp. 267 - 274 |
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| Language: | English |
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John Wiley & Sons, Inc
1999
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| Abstract | The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X‐rays and cyclophosphamide (CP) or X‐rays and mitomycin C (MMC) were investigated. Combinations of high (1.00 Gy + 100 mg/kg bw CP and 1.00 Gy + 5.25 mg/kg bw MMC) and low (0.25 Gy + 25 mg/kg bw CP and 0.25 Gy + 1.75 mg/kg bw MMC) doses were used. Both chemicals enhanced the mutagenic effects caused by irradiation. After combined treatment with high doses of X‐rays + CP and X‐rays + MMC at different sample times increases in frequency of micronuclei were observed. Mutagenic effects were found also after treatment with two low doses, when irradiation alone produced no effects. The effects of combined treatments are generally similar to the additive effect of the single treatments. Teratogenesis Carcinog. Mutagen. 19:267–274, 1999. © 1999 Wiley‐Liss, Inc. |
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| AbstractList | The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X‐rays and cyclophosphamide (CP) or X‐rays and mitomycin C (MMC) were investigated. Combinations of high (1.00 Gy + 100 mg/kg bw CP and 1.00 Gy + 5.25 mg/kg bw MMC) and low (0.25 Gy + 25 mg/kg bw CP and 0.25 Gy + 1.75 mg/kg bw MMC) doses were used. Both chemicals enhanced the mutagenic effects caused by irradiation. After combined treatment with high doses of X‐rays + CP and X‐rays + MMC at different sample times increases in frequency of micronuclei were observed. Mutagenic effects were found also after treatment with two low doses, when irradiation alone produced no effects. The effects of combined treatments are generally similar to the additive effect of the single treatments. Teratogenesis Carcinog. Mutagen. 19:267–274, 1999. © 1999 Wiley‐Liss, Inc. The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X-rays and cyclophosphamide (CP) or X-rays and mitomycin C (MMC) were investigated. Combinations of high (1.00 Gy + 100 mg/kg bw CP and 1. 00 Gy + 5.25 mg/kg bw MMC) and low (0.25 Gy + 25 mg/kg bw CP and 0. 25 Gy + 1.75 mg/kg bw MMC) doses were used. Both chemicals enhanced the mutagenic effects caused by irradiation. After combined treatment with high doses of X-rays + CP and X-rays + MMC at different sample times increases in frequency of micronuclei were observed. Mutagenic effects were found also after treatment with two low doses, when irradiation alone produced no effects. The effects of combined treatments are generally similar to the additive effect of the single treatments. |
| Author | Gajewski, Antoni K. Dobrzyńska, Malgorzata M. |
| Author_xml | – sequence: 1 givenname: Malgorzata M. surname: Dobrzyńska fullname: Dobrzyńska, Malgorzata M. organization: Department of Radiation Protection and Radiobiology, National Institute of Hygiene, Warsaw, Poland – sequence: 2 givenname: Antoni K. surname: Gajewski fullname: Gajewski, Antoni K. organization: Department of Biology, Academy of Physical Education, Warsaw, Poland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1901543$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10406890$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0165-1161(75)90007-2 10.1080/15287399209531652 10.1016/0165-1161(80)90193-4 10.1002/tcm.1770090406 10.1016/0165-1161(87)90073-2 10.1093/mutage/1.6.419 10.1016/0165-1161(75)90058-8 10.1016/0027-5107(91)90114-4 10.1016/0165-1218(94)00019-0 10.1016/0165-1218(78)90095-2 10.1016/0027-5107(81)90184-6 10.1016/0165-1218(87)90062-0 10.1002/(SICI)1520-6866(1997)17:2<45::AID-TCM1>3.0.CO;2-E 10.1016/0165-7992(82)90038-0 10.1016/0165-1218(89)90092-X 10.1016/0027-5107(96)00040-1 10.1016/0165-1161(92)90028-K 10.1016/0165-1161(90)90038-P 10.1016/0165-1161(95)00028-3 10.1007/BF00278901 10.1016/0165-1161(86)90049-X 10.1080/15287399209531599 10.1007/BF01210556 10.1016/0027-5107(92)90008-P 10.1007/978-1-4613-2127-9_33 10.1016/0165-7992(93)90032-Q 10.1016/0165-1218(89)90081-5 10.1016/0165-1218(89)90036-0 10.1016/0027-5107(83)90098-2 10.1016/0165-1161(90)90002-6 10.1002/tcm.1770150303 10.1016/0165-1218(89)90088-8 10.1007/BF01212678 10.1016/0027-5107(76)90104-4 10.1016/0027-5107(94)90032-9 10.1016/0165-1218(95)90050-0 10.1016/0165-1218(92)90216-M 10.1016/0165-7992(83)90052-0 10.1016/0027-5107(95)00039-L 10.1093/mutage/10.6.531 10.1016/0027-5107(73)90035-3 10.1080/09553009014550371 10.1016/0165-7992(91)90042-3 10.1016/0027-5107(81)90105-6 10.1007/BF00293661 10.1016/S0165-1218(96)90081-6 10.1016/0027-5107(92)90177-4 10.1016/0165-1218(91)90024-G 10.1016/0165-7992(92)90088-Y |
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| Issue | 4 |
| Keywords | Antineoplastic agent Mitomycin Micronucleus test Mutagenicity testing Toxicity Rodentia Red blood cell X ray Radiotherapy X ray irradiation Vertebrata Chemotherapy Cyclophosphamide Oxazaphosphinane derivatives Mammalia Mouse Animal DNA Nitrogen mustard Combined treatment Comparative study |
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Medline 1987; 189 1990; 57 1992; 282 1992; 284 1989; 278 1973; 18 1995; 335 1982; 105 1995; 330 1991; 264 1986; 1 1992; 271 1981; 80 1989; 222 1989; 223 1980; 74 1977; 38 1991; 260 1994; 33 1985 1997; 17 1997; 16 1982 1994; 306 1983; 109 1976; 41 1995; 15 1992; 266 1992; 301 1995; 10 1975; 31 1992; 35 1992 1978; 58 1992; 37 1996; 367 1990; 243 1994; 322 1979; 46 1991; 246 1983; 122 1989; 123 1986; 164 1990; 29 1995; 345 1990; 234 1996; 356 1989; 19 1987; 182 e_1_2_1_41_2 e_1_2_1_22_2 Jenssen D (e_1_2_1_24_2) 1982 e_1_2_1_45_2 e_1_2_1_20_2 e_1_2_1_43_2 e_1_2_1_26_2 e_1_2_1_49_2 e_1_2_1_47_2 e_1_2_1_28_2 Anderson D (e_1_2_1_44_2) 1997; 16 e_1_2_1_6_2 e_1_2_1_4_2 e_1_2_1_12_2 e_1_2_1_33_2 e_1_2_1_50_2 e_1_2_1_10_2 e_1_2_1_31_2 e_1_2_1_52_2 e_1_2_1_16_2 e_1_2_1_37_2 e_1_2_1_14_2 e_1_2_1_35_2 e_1_2_1_8_2 e_1_2_1_18_2 e_1_2_1_39_2 e_1_2_1_40_2 e_1_2_1_23_2 e_1_2_1_21_2 e_1_2_1_42_2 e_1_2_1_27_2 e_1_2_1_48_2 e_1_2_1_25_2 e_1_2_1_46_2 e_1_2_1_29_2 e_1_2_1_30_2 e_1_2_1_53_2 e_1_2_1_7_2 e_1_2_1_5_2 e_1_2_1_11_2 e_1_2_1_34_2 Fu KK (e_1_2_1_2_2) 1992 e_1_2_1_3_2 e_1_2_1_32_2 e_1_2_1_51_2 e_1_2_1_15_2 e_1_2_1_38_2 e_1_2_1_13_2 e_1_2_1_36_2 e_1_2_1_19_2 e_1_2_1_17_2 e_1_2_1_9_2 |
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| Snippet | The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X‐rays and cyclophosphamide (CP) or... The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X-rays and cyclophosphamide (CP) or... |
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| SubjectTerms | Animals Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - radiation effects combined treatment cyclophosphamide Cyclophosphamide - toxicity Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug toxicity and drugs side effects treatment Erythroid Precursor Cells - cytology Erythroid Precursor Cells - drug effects Erythroid Precursor Cells - radiation effects Male Medical sciences Mice Mice, Inbred Strains micronuclei Micronucleus Tests Miscellaneous (drug allergy, mutagens, teratogens...) Mitomycin - toxicity mitomycin C Pharmacology. Drug treatments Radiation therapy and radiosensitizing agent Time Factors Treatment with physical agents Treatment. General aspects Tumors Whole-Body Irradiation X-Rays |
| Title | Induction of micronuclei in mouse bone marrow after combined X-rays-cyclophosphamide and X-rays-mitomycin C treatments |
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