Retroperitoneal Castleman Disease Mimicking Paraganglioma in a Patient with Klinefelter Syndrome: A Case Report

• Published in: Turkish journal of endocrinology and metabolism Vol. 23; no. 2; pp. 130 - 134
• Main Authors: HEPŞEN, Sema, ÖZBEK, Mustafa, SENCAR, Erkam, AKHANLI, Pınar, ARIKÖK, Ata Türker, ŞEKER, Duray, ÜNSAL, İlknur, ÇAKAL, Erman
• Format: Journal Article
• Language: English
• Published: Ankara Türkiye Klinikleri 2019
• Subjects: Case reports; Metabolites; Neuroendocrine tumors
• ISSN: 1301-2193; 1308-9846
• DOI: 10.25179/tjem.2019-64815

Castleman disease progresses with the enlargement of the affected lymph nodes and represented by a wide range of symptoms. This lymphoproliferative disease rarely affects the retroperitoneum. A patient with Klinefelter syndrome was admitted to our clinic following palpitation and sweat attacks. It was observed that the urinary catecholamine metabolites were elevated and a pararenal mass was found on the left side. The patient was directed to surgery with the paraganglioma pre-diagnosis after further examination. Histopathological examination of the excised mass confirmed the diagnosis of Castleman disease. The urinary catecholamine metabolites returned to near-normal levels at eight weeks after the surgery. We present a case of Castleman disease in a patient with Klinefelter syndrome, imitating paraganglioma as per the clinical, radiological and laboratory findings.